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KMID : 0365819710110010139
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Journal of Pusan Medical College
1971 Volume.11 No. 1 p.139 ~ p.148
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Effect of Splenectomy on Tissue Storage Iron in Rabbits
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Abstract
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The author investigated the effect of splenectomy on the metabolism of tissue storage iron. Rabbits were used in this study. The spleen was removed by peritoneal approach. The changes in storage iron concentration of the liver, kidney and bone marrow were observed in the rabbits undergone splenectomy and in the splenectomized rabbits undergone phlebotomy, or given iron by oral route. The results thus obtained could be summarized as follows:
1. In the rabbits undergone splenectomy alone the storage iron concentration of the liver, kidney and bone marrow increased markedly.
2. In the splenectomized rabbits given iron the storage iron concentration of the liver, kidney and bone marrow increased more markedly than in the rabbits undergone splenectomy alone.
3. In the rabbits, non-splenectomized and splenectomized, undergone phlebotomy the storage iron concentration of the liver and bone marrow decreased in the early stage and increased in the late stage. The biphasic change in the concentration of tissue storage iron was more marked in the splenectomized cases.
In the splenectomized cases the storage iron concentraion of the kidney showed the late increase, but the normal cases no change following phlebotomy.
4. On the basis of the above, it is suggested that the increase of the concentration of tissue storage iron following splenectomy may be the result of enhanced iron absorption from the gastro-intestinal tract due to iron deficiency and increased erythropoiesis following splenectomy.
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